Radiation induced sarcomas – The Nottingham experience
نویسندگان
چکیده
منابع مشابه
Should Cancer Survivors Fear Radiation-Induced Sarcomas?
Purpose/Results. Ionizing radiation is carcinogenic and the induction of a second malignancy is a serious potential long-term complication of radiotherapy. The incidence of radiation-induced sarcomas was evaluated from many large epidemiological surveys of long-term cancer survivors reported in the literature over the past 30 years and only one case was found for every 1000 patients irradiated....
متن کاملRadiation-induced sarcomas of the head and neck.
The aim of this study was to report our experience on the management of radiation-induced sarcomas (RISs). A retrospective study from 1994 to 2003 was done at our institution reviewing the medical records of 5 patients who had RISs. Five patients diagnosed of head and neck cancer received irradiation to treat their diseases. Later on, these patients developed new neoplasms in the irradiation fi...
متن کاملSpecific TP53 mutation pattern in radiation-induced sarcomas.
The mutagenic properties of ionizing radiation are well known, but the presence of specific mutations in human radiation-induced tumours is not established. We have studied a series of 36 secondary sarcomas arising in the irradiation field of a primary tumour following radiotherapy. The allelic status and the presence of mutations of the TP53 gene were investigated. The mutation pattern was com...
متن کاملRadiation-induced sarcomas of bone: factors that affect outcome.
We identified 42 patients who presented to our unit over a 27-year period with a secondary radiation-induced sarcoma of bone. We reviewed patient, tumour and treatment factors to identify those that affected outcome. The mean age of the patients at presentation was 45.6 years (10 to 84) and the mean latent interval between radiotherapy and diagnosis of the sarcoma was 17 years (4 to 50). The me...
متن کاملA transcriptome signature distinguished sporadic from postradiotherapy radiation-induced sarcomas.
Exposure to ionizing radiation is a known risk factor for cancer. However, up to now, rigorously defined scientific criteria that could establish case-by-case the radiation-induced (RI) origin of a tumour have been lacking. To identify genes that could constitute a RI signature, we compared the transcriptome of 12 sarcomas arising in the irradiation field of a primary tumour following radiother...
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ژورنال
عنوان ژورنال: International Journal of Surgery
سال: 2012
ISSN: 1743-9191
DOI: 10.1016/j.ijsu.2012.06.343